MAP4K1

Across TCGA pan-cancer cohorts, MAP4K1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MAP4K1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MAP4K1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MAP4K1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, COAD, and PDAC are the cancer types where MAP4K1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.820	0.428	<.001	29	view →
COAD	DFS	Quartile	II,III,IV	0.898	1.000	.043	18	view →
PDAC	DFS	Tertile	II,III,IV	0.937	0.709	.001	18	view →
HNSC	OS	Quartile	III,IV	0.470	0.821	.011	7	view →
UCEC	DFS	Tertile	All	0.715	0.968	.015	4	view →
CCRCC	OS	Median	II,III,IV	1.000	0.067	.036	3	view →
LSCC	OS	Quartile	II,III,IV	0.535	0.863	.020	2	view →
GBM	OS	Quartile	All	0.684	0.912	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MAP4K1–LUAD (DFS)

Open the LUAD breakdown →