MAP4K1

Across TCGA patient cohorts, MAP4K1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K1-associated genes across cancer lineages are ASNS, ATM, and eIF4E. Each is linked with MAP4K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP4K1-to-partner and partner-to-MAP4K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MAP4K1-low versus MAP4K1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K1→partner) and Y-score (partner→MAP4K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.514	+3.000	.013	.035	3	3
UCEC	ATM →	-0.502	-2.687	<.001	.005	3	3
SKCM	eIF4E →	+0.174	+2.459	.040	.020	3	2
UCEC	INPP4B →	-0.310	-2.087	.003	.004	3	2
UCEC	mTOR_pS2448 →	-0.137	-1.828	.005	.007	3	2
UCEC	PDCD4 →	-0.586	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ASNS by MAP4K1 expression — SKCM

Explore this box plot interactively →