MAP4K1

Across TCGA cell cohorts, MAP4K1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAP4K1-associated genes across cancer lineages are COX6A2, IFNA14, and OR8B4. Each is linked with MAP4K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K1-to-partner and partner-to-MAP4K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by MAP4K1-low versus MAP4K1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K1→partner) and Y-score (partner→MAP4K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	COX6A2 →	+0.123	+5.087	<.001	.004	3	1
URINARY_TRACT	IFNA14 →	+0.026	+5.087	<.001	.004	3	1
URINARY_TRACT	OR8B4 →	+0.053	+5.087	<.001	.004	3	1
SKIN	WNT1 →	+0.033	+2.921	.001	.005	3	1
SKIN	SPATA48 →	+0.008	+3.240	<.001	.004	3	1
SKIN	ST8SIA3 →	+0.042	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

COX6A2 by MAP4K1 expression — URINARY_TRACT

Explore this box plot interactively →