MAP3K9

Across TCGA patient cohorts, MAP3K9 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K9-associated genes across cancer lineages are c-Kit, NF2, and C-Raf. Each is linked with MAP3K9 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K9-to-partner and partner-to-MAP3K9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by MAP3K9-low versus MAP3K9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K9→partner) and Y-score (partner→MAP3K9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.526	-2.115	.016	.017	3	3
COAD	NF2 →	+0.175	+2.820	.046	.035	3	3
COAD	C-Raf →	+0.155	+2.841	.018	.033	3	3
UCEC	MEK1 →	+0.378	+2.584	.003	.010	3	2
LUAD	MYH11 →	-0.966	-2.321	.022	.035	3	2
SKCM	INPP4B →	-0.152	-1.567	.017	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

c-Kit by MAP3K9 expression — SKCM

Explore this box plot interactively →