MAP3K9

Across TCGA cell cohorts, MAP3K9 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K9-associated genes across cancer lineages are STRA8, UGT2B10, and OR10AG1. Each is linked with MAP3K9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K9-to-partner and partner-to-MAP3K9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STRA8 grouped by MAP3K9-low versus MAP3K9-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K9→partner) and Y-score (partner→MAP3K9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STRA8 →	+0.152	+4.137	<.001	.001	3	1
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
PANCREAS	OR10AG1 →	+0.019	+5.000	<.001	.006	3	1
PANCREAS	MYH7 →	+0.006	+5.000	<.001	.006	3	1
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1
STOMACH	ZCCHC13 →	+0.033	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

STRA8 by MAP3K9 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →