MAP3K7

Across TCGA pan-cancer cohorts, MAP3K7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MAP3K7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAP3K7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAP3K7 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where MAP3K7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.261	<.001	10	view →
HNSC	Male	III,IV	+0.321	<.001	8	view →
CCRCC	Male	All	−0.211	<.001	8	view →
LSCC	All	II,III,IV	+0.123	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MAP3K7–COAD

Open the COAD breakdown →