MAP3K7

Across TCGA patient cohorts, MAP3K7 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K7-associated genes across cancer lineages are ATM, 14-3-3_beta, and ERK2. Each is linked with MAP3K7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K7-to-partner and partner-to-MAP3K7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MAP3K7-low versus MAP3K7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K7→partner) and Y-score (partner→MAP3K7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.473	-2.446	.003	.018	3	2
UCEC	14-3-3_beta →	-0.095	-2.558	.007	.010	3	1
UCEC	ERK2 →	+0.166	+1.362	.014	.037	3	1
UCEC	Heregulin →	-0.119	-3.087	.006	<.001	3	1
UCEC	INPP4B →	-0.277	-2.000	.015	.009	3	1
UCEC	JNK2 →	+0.267	+3.611	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by MAP3K7 expression — UCEC

Explore this box plot interactively →