MAP3K7

Across TCGA cell cohorts, MAP3K7 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K7-associated genes across cancer lineages are DEFA4, PRND, and C2orf73. Each is linked with MAP3K7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K7-to-partner and partner-to-MAP3K7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by MAP3K7-low versus MAP3K7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K7→partner) and Y-score (partner→MAP3K7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRND →	+0.022	+3.878	.007	.003	3	1
LARGE_INTESTINE	C2orf73 →	+0.057	+3.443	.009	.009	2	2
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TAS2R60 →	+0.017	+3.347	.005	.005	3	1
LARGE_INTESTINE	BPIFA1 →	+0.149	+5.009	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

DEFA4 by MAP3K7 expression — LARGE_INTESTINE

Explore this box plot interactively →