MAP3K6

Across TCGA patient cohorts, MAP3K6 protein abundance is significantly associated with the RNA expression of many other genes, with 11,559 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAP3K6-associated genes across cancer lineages are MAP3K5, NFKBIZ, and GNA15. Each is linked with MAP3K6 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAP3K6-to-partner and partner-to-MAP3K6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP3K6 versus MAP3K5 in UCEC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K6→partner) and Y-score (partner→MAP3K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP3K5 →	+0.976	+0.465	<.001	<.001	3	7
GBM	NFKBIZ →	+1.103	+0.350	<.001	<.001	3	6
GBM	GNA15 →	+1.258	+0.397	<.001	<.001	3	6
GBM	TREM1 →	+1.770	+0.433	<.001	<.001	3	5
LUAD	LINC02015 →	+0.704	+0.220	<.001	<.001	3	5
LUAD	CRYBG1 →	+0.949	+0.274	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,559 associations by consensus.

MAP3K6 vs MAP3K5 — UCEC

Explore this scatter interactively →