MAP3K6

Across TCGA patient cohorts, MAP3K6 mutation is significantly associated with the RNA expression of many other genes, with 2,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K6-associated genes across cancer lineages are UHRF1, OR8B8, and PELO. Each is linked with MAP3K6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K6-to-partner and partner-to-MAP3K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by MAP3K6-low versus MAP3K6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K6→partner) and Y-score (partner→MAP3K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.861	+2.332	<.001	<.001	3	3
BLCA	OR8B8 →	+0.029	+3.677	<.001	.002	3	3
UCEC	PELO →	+0.395	+2.818	.005	<.001	3	3
UCEC	CCNB2 →	+0.620	+1.925	.004	.005	3	3
UCEC	PSMD6 →	+0.300	+3.523	.007	.002	3	3
UCEC	PGAM1 →	+0.656	+2.243	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,153 associations by consensus.

UHRF1 by MAP3K6 expression — UCEC

Explore this box plot interactively →