MAP3K6

Across TCGA cell cohorts, MAP3K6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,477 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAP3K6-associated GO terms across cancer lineages are Assembly of actomyosin apparatus involved in cytokinesis, Actomyosin contractile ring assembly, and Actomyosin contractile ring assembly actin filament organization. Each is linked with MAP3K6 in more than 12 cancer types. Because this analysis shows association rather than direction, both MAP3K6-to-partner and partner-to-MAP3K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Assembly of actomyosin apparatus involved in cytokinesis grouped by MAP3K6-low versus MAP3K6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K6→partner) and Y-score (partner→MAP3K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Assembly of actomyosin apparatus involved in cytokinesis →	+0.162	+1.175	<.001	<.001	3	13
BONE	Actomyosin contractile ring assembly →	+0.162	+1.175	<.001	<.001	3	13
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.235	+1.175	<.001	<.001	3	12
BONE	Response to water →	+0.221	+1.849	<.001	<.001	3	11
BONE	Positive regulation of neuromuscular junction development →	+0.256	+1.176	.005	.005	3	10
LUNG_NSCLC_LUAD	P38MAPK cascade →	+0.115	+1.072	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,477 associations by consensus.

Assembly of actomyosin apparatus involved in cytokinesis by MAP3K6 expression — BONE

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