MAP3K6

Across TCGA cell cohorts, MAP3K6 mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K6-associated genes across cancer lineages are MAGEE2, CCT8L2, and MS4A6E. Each is linked with MAP3K6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K6-to-partner and partner-to-MAP3K6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEE2 grouped by MAP3K6-low versus MAP3K6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K6→partner) and Y-score (partner→MAP3K6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEE2 →	+0.047	+3.658	<.001	.005	3	2
SKIN	CCT8L2 →	+0.043	+4.022	<.001	.006	3	2
LUNG_NSCLC_LUAD	MS4A6E →	+0.044	+5.228	<.001	.005	3	2
LARGE_INTESTINE	TNRC6B →	+0.735	+3.234	<.001	.004	3	2
LARGE_INTESTINE	USP14 →	+0.572	+3.087	.007	.006	3	2
LARGE_INTESTINE	RNMT →	+0.711	+2.675	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

MAGEE2 by MAP3K6 expression — SKIN

Explore this box plot interactively →