Across TCGA patient cohorts, MAP3K5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,210 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAP3K5-associated proteins across cancer lineages are MAP3K6, MAP3K6_S964, and MAP3K5_S1033. Each is linked with MAP3K5 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAP3K5-to-partner and partner-to-MAP3K5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K5→partner) and Y-score (partner→MAP3K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP3K6 →	+0.465	+0.976	<.001	<.001	3	7
OV	MAP3K6_S964 →	+0.890	+0.699	<.001	.001	3	7
BRCA	MAP3K5_S1033 →	+0.755	+1.026	<.001	<.001	3	6
BRCA	DARS2 →	-0.509	-0.831	<.001	<.001	3	6
LSCC	MED8 →	-0.269	-0.493	.002	.003	3	5
UCEC	MAP3K5_S958 →	+0.568	+0.739	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,210 associations by consensus.

Exploration

MAP3K5 survival (RNA) · tumor vs normal (RNA) · all MAP3K5 data types