Across TCGA patient cohorts, MAP3K5 mutation is significantly associated with the RNA expression of many other genes, with 4,715 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K5-associated genes across cancer lineages are CNOT9, UFL1-AS1, and HAUS1. Each is linked with MAP3K5 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K5-to-partner and partner-to-MAP3K5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K5→partner) and Y-score (partner→MAP3K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNOT9 →	+0.292	+1.450	<.001	<.001	3	4
SKCM	UFL1-AS1 →	+0.063	+1.499	.005	.003	3	4
UCEC	HAUS1 →	+0.375	+1.312	.002	.002	3	3
UCEC	EME1 →	+0.549	+1.595	<.001	<.001	3	3
SKCM	RACGAP1 →	+0.553	+1.855	<.001	<.001	3	3
UCEC	TEDC2 →	+0.534	+1.771	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,715 associations by consensus.

Exploration

MAP3K5 survival (RNA) · tumor vs normal (RNA) · all MAP3K5 data types