Across TCGA patient cohorts, MAP3K5 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K5-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Cyclin-B1. Each is linked with MAP3K5 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K5-to-partner and partner-to-MAP3K5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K5→partner) and Y-score (partner→MAP3K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.448	+1.534	.008	.008	3	4
COAD	PCNA →	+0.372	+2.815	.006	.036	3	3
UCEC	Cyclin-B1 →	+0.752	+1.954	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.339	+1.954	<.001	<.001	3	3
UCEC	eIF4E →	+0.146	+1.874	.016	.002	3	2
UCEC	eIF4G →	+0.236	+1.169	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

MAP3K5 survival (RNA) · tumor vs normal (RNA) · all MAP3K5 data types