Across TCGA cell cohorts, MAP3K5 mutation is significantly associated with the RNA expression of many other genes, with 111 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K5-associated genes across cancer lineages are KRTAP11-1, TMEM132C, and PROP1. Each is linked with MAP3K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K5-to-partner and partner-to-MAP3K5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K5→partner) and Y-score (partner→MAP3K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	2
BLOOD_Leukemia	TMEM132C →	+0.550	+2.644	<.001	.008	3	2
LARGE_INTESTINE	PROP1 →	+0.022	+2.639	<.001	.002	3	2
LARGE_INTESTINE	FAM72B →	+1.174	+3.212	.001	.006	3	2
URINARY_TRACT	UNCX →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	MRGPRE →	+0.021	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

Exploration

MAP3K5 survival (RNA) · tumor vs normal (RNA) · all MAP3K5 data types