Across TCGA patient cohorts, MAP3K3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,330 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAP3K3-associated genes across cancer lineages are GIMAP5, CAV1, and CNRIP1. Each is linked with MAP3K3 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAP3K3-to-partner and partner-to-MAP3K3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K3→partner) and Y-score (partner→MAP3K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GIMAP5 →	+0.632	+0.249	<.001	<.001	3	6
GBM	CAV1 →	+1.075	+0.432	.002	<.001	3	5
UCEC	CNRIP1 →	+0.628	+0.294	<.001	<.001	3	5
LSCC	NCKAP1L →	+0.840	+0.277	<.001	<.001	3	5
BRCA	GIMAP6 →	+0.751	+0.361	.001	<.001	3	5
HNSC	CLEC1A →	+0.876	+0.784	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,330 associations by consensus.

Exploration

MAP3K3 survival (RNA) · tumor vs normal (RNA) · all MAP3K3 data types