Across TCGA patient cohorts, MAP3K3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K3-associated genes across cancer lineages are eEF2, ERK2, and JNK2. Each is linked with MAP3K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K3-to-partner and partner-to-MAP3K3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K3→partner) and Y-score (partner→MAP3K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.269	+2.000	.022	.029	3	2
UCEC	ERK2 →	+0.164	+2.584	.009	.010	3	2
UCEC	JNK2 →	+0.210	+2.249	.001	.005	3	2
UCEC	Rictor_pT1135 →	-0.089	-1.906	.008	.015	3	2
UCEC	TFRC →	+0.539	+2.115	.002	.016	3	2
UCEC	Cyclin-B1 →	+0.716	+1.938	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

MAP3K3 survival (RNA) · tumor vs normal (RNA) · all MAP3K3 data types