MAP3K2

Across TCGA cell cohorts, MAP3K2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,652 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K2-associated GO terms across cancer lineages are Regulation of translational initiation, Cytosolic transport, and Phosphatidylinositol biosynthetic process. Each is linked with MAP3K2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MAP3K2-to-partner and partner-to-MAP3K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by MAP3K2-low versus MAP3K2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K2→partner) and Y-score (partner→MAP3K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of translational initiation →	+0.106	+0.935	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.081	+0.816	<.001	.007	3	17
BONE	Phosphatidylinositol biosynthetic process →	+0.062	+0.879	.003	.002	3	16
BONE	Endosomal transport →	+0.066	+1.009	.009	.001	3	16
BREAST	Protein deubiquitination →	+0.068	+0.977	<.001	<.001	3	16
OESOPHAGUS	Peptidyl-serine phosphorylation →	+0.077	+0.646	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,652 associations by consensus.

Regulation of translational initiation by MAP3K2 expression — OVARY

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