MAP3K2

Across TCGA cell cohorts, MAP3K2 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K2-associated genes across cancer lineages are FSHB, TSKS, and TRIM60. Each is linked with MAP3K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K2-to-partner and partner-to-MAP3K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by MAP3K2-low versus MAP3K2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K2→partner) and Y-score (partner→MAP3K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSHB →	+0.007	+3.925	<.001	.006	3	2
CNS	TSKS →	+0.066	+2.353	.004	.008	3	2
BLOOD_Leukemia	TRIM60 →	+0.016	+3.464	<.001	.003	3	2
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUSC	KRTAP16-1 →	+0.043	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OPN1MW3 →	+0.273	+4.643	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

FSHB by MAP3K2 expression — BLOOD_Lymphoma

Explore this box plot interactively →