MAP3K2-DT

Across TCGA pan-cancer cohorts, MAP3K2-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MAP3K2-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAP3K2-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAP3K2-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and OV show a favorable association.

KIRC, SKCM, and OV are the cancer types where MAP3K2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.544	0.732	<.001	70	view →
SKCM	OS	Median	All	0.403	0.274	<.001	70	view →
OV	OS	Tertile	III,IV	0.768	0.617	.001	52	view →
UVM	OS	Tertile	All	0.461	0.896	.009	35	view →
KIRP	DFS	Quartile	All	0.776	0.963	.001	32	view →
UCS	DFS	Quartile	All	0.669	0.292	.005	18	view →
COAD	OS	Quartile	All	0.520	0.710	.012	16	view →
LAML	DFS	Median	All	0.454	0.686	.015	16	view →
PAAD	DFS	Quartile	II,III,IV	0.494	0.327	.016	14	view →
CHOL	OS	Tertile	All	0.452	0.905	.006	12	view →
UCEC	DFS	Median	IV	0.285	0.623	.020	12	view →
KICH	OS	Median	III,IV	0.609	0.928	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MAP3K2-DT–KIRC (OS)

Open the KIRC breakdown →