MAP3K19

Across TCGA patient cohorts, MAP3K19 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K19-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and GAPDH. Each is linked with MAP3K19 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K19-to-partner and partner-to-MAP3K19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP3K19-low versus MAP3K19-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K19→partner) and Y-score (partner→MAP3K19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.259	+3.008	.002	.019	3	4
LUSC	FoxM1 →	+0.338	+3.459	.001	.005	3	3
COAD	GAPDH →	+0.865	+3.008	<.001	.019	3	3
UCEC	MEK1 →	+0.445	+1.632	<.001	<.001	3	3
COAD	TSC1 →	-0.347	-2.991	.015	.036	3	3
UCEC	eIF4E →	+0.193	+1.830	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Caspase-7-cleavedD198 by MAP3K19 expression — COAD

Explore this box plot interactively →