MAP3K19

Across TCGA cell cohorts, MAP3K19 mutation is significantly associated with the RNA expression of many other genes, with 475 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K19-associated genes across cancer lineages are USP46, DENND10, and RPAP2. Each is linked with MAP3K19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K19-to-partner and partner-to-MAP3K19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP46 grouped by MAP3K19-low versus MAP3K19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K19→partner) and Y-score (partner→MAP3K19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP46 →	+0.585	+2.451	.009	.009	3	2
LARGE_INTESTINE	DENND10 →	+0.586	+3.321	.002	.003	3	2
LARGE_INTESTINE	RPAP2 →	+0.768	+3.321	<.001	.003	3	2
LARGE_INTESTINE	MKLN1 →	+0.435	+2.451	.008	.009	3	2
LARGE_INTESTINE	FBXO25 →	+1.000	+3.502	<.001	.001	3	2
LARGE_INTESTINE	LZIC →	+0.524	+3.502	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 475 associations by consensus.

USP46 by MAP3K19 expression — LARGE_INTESTINE

Explore this box plot interactively →