MAP3K12

Across TCGA patient cohorts, MAP3K12 mutation is significantly associated with the RNA expression of many other genes, with 3,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K12-associated genes across cancer lineages are PSAT1P4, THRB, and GFI1. Each is linked with MAP3K12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K12-to-partner and partner-to-MAP3K12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by MAP3K12-low versus MAP3K12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K12→partner) and Y-score (partner→MAP3K12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PSAT1P4 →	+0.116	+4.623	<.001	.001	3	3
COAD	THRB →	-0.618	-2.893	.005	.001	3	2
COAD	GFI1 →	+0.840	+2.605	.001	.005	3	2
UCEC	MRM3 →	+0.414	+1.797	<.001	<.001	3	2
UCEC	MAB21L4 →	-1.073	-2.652	<.001	<.001	3	2
UCEC	TOP3A →	+0.591	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,219 associations by consensus.

PSAT1P4 by MAP3K12 expression — BLCA

Explore this box plot interactively →