MAP3K12

Across TCGA patient cohorts, MAP3K12 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K12-associated genes across cancer lineages are EGFR_pY1068, Cyclin-E2, and FoxM1. Each is linked with MAP3K12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K12-to-partner and partner-to-MAP3K12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAP3K12-low versus MAP3K12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K12→partner) and Y-score (partner→MAP3K12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.226	-1.652	.006	.006	3	3
COAD	Cyclin-E2 →	+0.269	+2.832	.007	.034	3	3
UCEC	FoxM1 →	+0.244	+2.425	.004	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.087	-1.575	.034	.017	3	2
UCEC	JNK_pT183_Y185 →	-0.161	-1.700	.003	.040	3	2
UCEC	MEK1 →	+0.473	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by MAP3K12 expression — UCEC

Explore this box plot interactively →