MAP3K12

Across TCGA cell cohorts, MAP3K12 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K12-associated genes across cancer lineages are DEFB133, BANF2, and OR52E2. Each is linked with MAP3K12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K12-to-partner and partner-to-MAP3K12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB133 grouped by MAP3K12-low versus MAP3K12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K12→partner) and Y-score (partner→MAP3K12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB133 →	+0.084	+5.228	.003	.005	3	2
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR52E2 →	+0.341	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.207	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	1
BLOOD_Leukemia	TSPO →	-2.853	-3.232	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

DEFB133 by MAP3K12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →