MAP3K11

Across TCGA patient cohorts, MAP3K11 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K11-associated genes across cancer lineages are eIF4E, CDK1, and Annexin-1. Each is linked with MAP3K11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K11-to-partner and partner-to-MAP3K11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MAP3K11-low versus MAP3K11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K11→partner) and Y-score (partner→MAP3K11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.243	+3.087	.004	<.001	3	2
COAD	CDK1 →	+0.298	+2.178	<.001	.035	3	2
UCEC	Annexin-1 →	+0.594	+2.584	.005	.010	3	2
UCEC	Stathmin →	+0.127	+1.906	.022	.016	3	2
UCEC	ATM →	-0.635	-2.446	<.001	.018	3	2
COAD	Heregulin →	+0.225	+2.212	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eIF4E by MAP3K11 expression — UCEC

Explore this box plot interactively →