MAP3K11

Across TCGA cell cohorts, MAP3K11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,121 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAP3K11-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Cellular response to nicotine, and Regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with MAP3K11 in more than 13 cancer types. Because this analysis shows association rather than direction, both MAP3K11-to-partner and partner-to-MAP3K11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by MAP3K11-low versus MAP3K11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K11→partner) and Y-score (partner→MAP3K11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.202	+1.096	<.001	<.001	3	14
LUNG_SCLC	Cellular response to nicotine →	+0.199	+0.976	<.001	<.001	3	14
BONE	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.212	+1.243	.001	<.001	3	13
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.085	+1.040	<.001	<.001	3	12
BONE	Regulation of metaphase plate congression →	+0.135	+0.845	.001	<.001	3	12
BONE	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.234	+1.222	.002	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,121 associations by consensus.

Transcription pausing by RNA polymerase II by MAP3K11 expression — BONE

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