MAP3K11

Across TCGA cell cohorts, MAP3K11 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K11-associated genes across cancer lineages are ELOVL4, HTN1, and VWC2L. Each is linked with MAP3K11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K11-to-partner and partner-to-MAP3K11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOVL4 grouped by MAP3K11-low versus MAP3K11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K11→partner) and Y-score (partner→MAP3K11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOVL4 →	+0.603	+3.443	.003	.009	3	2
LARGE_INTESTINE	HTN1 →	+0.189	+2.688	<.001	.008	3	2
LARGE_INTESTINE	VWC2L →	+0.008	+3.345	<.001	.001	3	2
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	GALR3 →	+0.153	+3.602	<.001	.005	3	1
LARGE_INTESTINE	KLHDC7B →	+0.629	+3.707	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ELOVL4 by MAP3K11 expression — LARGE_INTESTINE

Explore this box plot interactively →