MAP3K10

Across TCGA pan-cancer cohorts, MAP3K10 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MAP3K10 data layer compared with 29 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MAP3K10 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP3K10 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BRCA, LIHC, and UCEC are the cancer types where MAP3K10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.509	0.903	<.001	16	view →
LIHC	DFS	Median	II,III,IV	0.040	0.427	<.001	12	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
BLCA	OS	Median	IV	0.231	0.602	.022	6	view →
SKCM	DFS	Median	III,IV	0.844	0.490	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MAP3K10–BRCA (DFS)

Open the BRCA breakdown →