MAP3K1

Across TCGA pan-cancer cohorts, MAP3K1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MAP3K1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MAP3K1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MAP3K1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where MAP3K1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.494	.021	4	view →
HNSC	OS	Tertile	All	0.806	0.561	.027	3	view →
CCRCC	OS	Quartile	All	1.000	0.747	.017	3	view →
LUAD	OS	Median	III,IV	0.808	0.411	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MAP3K1–UCEC (OS)

Open the UCEC breakdown →