MAP3K1

Across TCGA patient cohorts, MAP3K1 mutation is significantly associated with the RNA expression of many other genes, with 4,853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K1-associated genes across cancer lineages are SNORD113-2, BFAR, and CAMTA2. Each is linked with MAP3K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K1-to-partner and partner-to-MAP3K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD113-2 grouped by MAP3K1-low versus MAP3K1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K1→partner) and Y-score (partner→MAP3K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SNORD113-2 →	+0.739	+5.305	<.001	.003	3	3
BRCA	BFAR →	+0.248	+2.760	.004	.003	3	3
BRCA	CAMTA2 →	+0.355	+2.528	.004	<.001	3	3
BRCA	RNF167 →	+0.299	+2.169	.003	<.001	3	3
BRCA	MED31 →	+0.453	+3.665	<.001	<.001	3	3
BRCA	DRG2 →	+0.282	+2.148	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,853 associations by consensus.

SNORD113-2 by MAP3K1 expression — LIHC

Explore this box plot interactively →