MAP3K1

Across TCGA cell cohorts, MAP3K1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,507 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MAP3K1-associated GO terms across cancer lineages are Actin filament-based transport, Protein localization to lysosome, and Phospholipid biosynthetic process. Each is linked with MAP3K1 in more than 9 cancer types. Because this analysis shows association rather than direction, both MAP3K1-to-partner and partner-to-MAP3K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament-based transport grouped by MAP3K1-low versus MAP3K1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K1→partner) and Y-score (partner→MAP3K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Actin filament-based transport →	+0.115	+0.818	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Protein localization to lysosome →	+0.098	+1.211	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.049	+0.815	.002	.006	2	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of L-glutamate import across plasma membrane →	+0.051	+0.960	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.101	+0.990	<.001	.002	3	8
KIDNEY	Negative regulation of actin filament polymerization →	+0.127	+1.230	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

Actin filament-based transport by MAP3K1 expression — BREAST

Explore this box plot interactively →