MAP3K1

Across TCGA cell cohorts, MAP3K1 mutation is significantly associated with the RNA expression of many other genes, with 500 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K1-associated genes across cancer lineages are HMGCR, PANK3, and DLAT. Each is linked with MAP3K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K1-to-partner and partner-to-MAP3K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGCR grouped by MAP3K1-low versus MAP3K1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K1→partner) and Y-score (partner→MAP3K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HMGCR →	+0.776	+3.412	.002	.002	3	2
BLOOD_Leukemia	PANK3 →	+0.568	+3.548	.007	.001	3	2
BLOOD_Leukemia	DLAT →	+0.717	+3.489	<.001	.001	3	2
BLOOD_Leukemia	MAP6D1 →	+0.617	+3.115	.001	.009	3	2
BLOOD_Leukemia	CSNK2B →	+0.364	+3.215	.003	.005	3	2
BLOOD_Leukemia	DEPDC1 →	+1.071	+2.415	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

HMGCR by MAP3K1 expression — BLOOD_Leukemia

Explore this box plot interactively →