MAP2K7

Across TCGA pan-cancer cohorts, MAP2K7 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MAP2K7 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAP2K7 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP2K7 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

HNSC, THYM, and LIHC are the cancer types where MAP2K7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	III,IV	1.000	0.221	.018	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SARC	DFS	Median	All	0.130	0.632	.045	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
BLCA	DFS	Median	III,IV	1.000	0.538	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MAP2K7–HNSC (DFS)

Open the HNSC breakdown →