MAP2K7

Across TCGA pan-cancer cohorts, MAP2K7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MAP2K7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAP2K7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAP2K7 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where MAP2K7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP2K7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.462	<.001	9	view →
LUAD	All	III,IV	−0.189	<.001	9	view →
LSCC	All	All	−0.081	.002	7	view →
HNSC	Female	All	+0.335	.005	5	view →
CCRCC	Male	All	+0.060	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MAP2K7–COAD

Open the COAD breakdown →