MAP2K7

Across TCGA patient cohorts, MAP2K7 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MAP2K7-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and PRDX1. Each is linked with MAP2K7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP2K7-to-partner and partner-to-MAP2K7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP2K7-low versus MAP2K7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K7→partner) and Y-score (partner→MAP2K7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.062	+2.824	.002	.034	3	3
UCEC	Lck →	+0.234	+1.700	.006	.044	3	2
UCEC	PRDX1 →	+0.216	+2.584	.013	.010	3	2
UCEC	Rad50 →	-0.236	-1.700	.022	.044	3	2
UCEC	Annexin-1 →	+0.624	+3.459	.005	.005	3	2
UCEC	Bcl-2 →	-0.312	-1.673	.034	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by MAP2K7 expression — COAD

Explore this box plot interactively →