MAP2K7

Across TCGA cell cohorts, MAP2K7 mutation is significantly associated with the RNA expression of many other genes, with 202 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP2K7-associated genes across cancer lineages are CST9L, PNLIPRP1, and OR13C5. Each is linked with MAP2K7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K7-to-partner and partner-to-MAP2K7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9L grouped by MAP2K7-low versus MAP2K7-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K7→partner) and Y-score (partner→MAP2K7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CST9L →	+0.032	+5.369	<.001	.004	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
OVARY	OR13C5 →	+0.018	+5.339	<.001	<.001	3	1
OVARY	ZPBP →	+0.070	+4.029	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.023	+3.475	<.001	.006	3	1
BLOOD_Leukemia	SOX1 →	+0.403	+3.771	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 202 associations by consensus.

CST9L by MAP2K7 expression — SOFT_TISSUE

Explore this box plot interactively →