MAP2K5

Across TCGA patient cohorts, MAP2K5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K5-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with MAP2K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K5-to-partner and partner-to-MAP2K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MAP2K5-low versus MAP2K5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K5→partner) and Y-score (partner→MAP2K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.116	+1.710	.021	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.624	+3.827	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.126	-2.780	<.001	.003	3	1
UCEC	Heregulin →	-0.144	-3.446	.001	.005	3	1
UCEC	INPP4B →	-0.324	-2.807	.005	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-2.115	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by MAP2K5 expression — UCEC

Explore this box plot interactively →