MAP2K5

Across TCGA cell cohorts, MAP2K5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP2K5-associated genes across cancer lineages are XAGE5, OR2T8, and USP17L3. Each is linked with MAP2K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K5-to-partner and partner-to-MAP2K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by MAP2K5-low versus MAP2K5-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K5→partner) and Y-score (partner→MAP2K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	XAGE5 →	+0.066	+4.906	<.001	.006	3	1
OESOPHAGUS	OR2T8 →	+0.030	+4.906	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	C18orf63 →	+0.019	+4.867	<.001	.009	3	1
LUNG_SCLC	MYL10 →	+0.071	+4.523	.001	.003	3	1
LUNG_SCLC	USP17L11 →	+0.013	+4.523	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

XAGE5 by MAP2K5 expression — OESOPHAGUS

Explore this box plot interactively →