MAP2K4

Across TCGA pan-cancer cohorts, MAP2K4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MAP2K4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAP2K4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAP2K4 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where MAP2K4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP2K4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.459	<.001	11	view →
PDAC	Male	All	−0.332	<.001	8	view →
LSCC	All	II,III,IV	−0.147	<.001	8	view →
CCRCC	All	IV	−0.229	<.001	7	view →
HNSC	All	All	−0.078	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MAP2K4–COAD

Open the COAD breakdown →