MAP2K4

Across TCGA patient cohorts, MAP2K4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,750 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAP2K4-associated proteins across cancer lineages are PAFAH1B1, TTC19, and YWHAE. Each is linked with MAP2K4 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAP2K4-to-partner and partner-to-MAP2K4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAP2K4 versus PAFAH1B1 in LSCC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K4→partner) and Y-score (partner→MAP2K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PAFAH1B1 →	+0.216	+0.577	<.001	<.001	3	6
BRCA	TTC19 →	+0.392	+0.661	<.001	<.001	3	6
GBM	YWHAE →	+0.258	+0.401	<.001	<.001	3	6
COAD	CRK →	+0.259	+0.481	<.001	.001	3	6
COAD	FXR2 →	+0.293	+0.523	<.001	<.001	3	6
GBM	PRDX4 →	-0.592	-0.740	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,750 associations by consensus.

MAP2K4 vs PAFAH1B1 — LSCC

Explore this scatter interactively →