MAP2K4

Across TCGA cell cohorts, MAP2K4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,885 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP2K4-associated GO terms across cancer lineages are Cytosolic ciliogenesis, Mitotic nuclear division, and Protein localization to microtubule cytoskeleton. Each is linked with MAP2K4 in more than 13 cancer types. Because this analysis shows association rather than direction, both MAP2K4-to-partner and partner-to-MAP2K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic ciliogenesis grouped by MAP2K4-low versus MAP2K4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K4→partner) and Y-score (partner→MAP2K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytosolic ciliogenesis →	+0.121	+0.638	<.001	<.001	3	14
BREAST	Mitotic nuclear division →	+0.087	+0.909	.001	.002	2	13
UPPER_AERODIGESTIVE_TRACT	Protein localization to microtubule cytoskeleton →	+0.066	+0.605	.003	.002	3	11
STOMACH	Regulation of translation at synapse, modulating synaptic transmission →	+0.153	+1.047	<.001	.001	2	12
BLOOD_Lymphoma	Regulation of RNA export from nucleus →	+0.105	+0.793	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cell division →	+0.072	+0.594	.003	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,885 associations by consensus.

Cytosolic ciliogenesis by MAP2K4 expression — LUNG_SCLC

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