MAP2K4

Across TCGA cell cohorts, MAP2K4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP2K4-associated genes across cancer lineages are SMIM23, DPRX, and CNNM2. Each is linked with MAP2K4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K4-to-partner and partner-to-MAP2K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by MAP2K4-low versus MAP2K4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K4→partner) and Y-score (partner→MAP2K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM23 →	+0.637	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DPRX →	+0.273	+5.228	<.001	.005	3	1
LARGE_INTESTINE	CNNM2 →	+0.643	+3.064	.006	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.159	+2.560	.001	.008	3	1
LARGE_INTESTINE	CCDC195 →	+0.027	+2.560	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SMIM23 by MAP2K4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →