MAP2K2

Across TCGA patient cohorts, MAP2K2 mutation is significantly associated with the RNA expression of many other genes, with 1,694 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K2-associated genes across cancer lineages are RNU6-25P, RNY4P29, and SETP10. Each is linked with MAP2K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K2-to-partner and partner-to-MAP2K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-25P grouped by MAP2K2-low versus MAP2K2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K2→partner) and Y-score (partner→MAP2K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-25P →	+0.408	+3.974	.004	.006	3	2
BRCA	RNY4P29 →	+0.293	+8.055	<.001	.007	3	2
SKCM	SETP10 →	+0.070	+3.526	<.001	.005	3	2
UCEC	CENPU →	+0.747	+3.280	<.001	<.001	3	2
UCEC	SKA1 →	+0.847	+3.258	<.001	<.001	3	2
UCEC	ABHD3 →	+0.556	+3.480	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,694 associations by consensus.

RNU6-25P by MAP2K2 expression — HNSC

Explore this box plot interactively →