MAP2K2

Across TCGA patient cohorts, MAP2K2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K2-associated genes across cancer lineages are p70-S6K_pT389, PDCD4, and Caspase-7-cleavedD198. Each is linked with MAP2K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K2-to-partner and partner-to-MAP2K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by MAP2K2-low versus MAP2K2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K2→partner) and Y-score (partner→MAP2K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.166	-3.169	.046	.018	3	2
UCEC	PDCD4 →	-0.520	-2.807	.011	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+1.250	+3.906	<.001	<.001	3	2
UCEC	Chk2_pT68 →	-0.182	-2.973	.025	.035	3	2
COAD	JNK2 →	+0.290	+3.008	.002	.019	3	2
UCEC	14-3-3_beta →	-0.106	-2.973	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p70-S6K_pT389 by MAP2K2 expression — UCEC

Explore this box plot interactively →