MAP2K2

Across TCGA cell cohorts, MAP2K2 mutation is significantly associated with the mutation status of many other genes, with 2,031 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP2K2-associated genes across cancer lineages are HECW2, ETV6, and NPR2. Each is linked with MAP2K2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP2K2-to-partner and partner-to-MAP2K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HECW2 grouped by MAP2K2-low versus MAP2K2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K2→partner) and Y-score (partner→MAP2K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HECW2 →	+2.285	+3.364	.006	.006	1	4
BLOOD_Leukemia	ETV6 →	+3.063	+3.498	.006	.006	1	3
BLOOD_Leukemia	NPR2 →	+3.285	+3.662	.004	.004	1	3
BLOOD_Leukemia	TOR2A →	+3.870	+4.050	.002	.002	1	3
BLOOD_Leukemia	KLHL10 →	+3.870	+4.050	.002	.002	1	3
BLOOD_Leukemia	WASHC5 →	+3.285	+3.662	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

HECW2 by MAP2K2 expression — BLOOD_Leukemia

Explore this box plot interactively →