MAP2K1

Across TCGA patient cohorts, MAP2K1 mutation is significantly associated with the RNA expression of many other genes, with 883 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MAP2K1-associated genes across cancer lineages are SRIP3, SLC25A27, and TRAJ47. Each is linked with MAP2K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP2K1-to-partner and partner-to-MAP2K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRIP3 grouped by MAP2K1-low versus MAP2K1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K1→partner) and Y-score (partner→MAP2K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SRIP3 →	+0.100	+1.826	<.001	.003	3	3
UCEC	SLC25A27 →	-0.709	-2.692	.004	.006	3	2
CESC	TRAJ47 →	+0.466	+3.684	<.001	.005	3	2
CESC	SDCBPP1 →	+0.095	+3.825	<.001	.005	3	2
SKCM	LDHAP7 →	+0.714	+2.916	.003	<.001	3	2
SKCM	GCNT1P2 →	+0.032	+2.159	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 883 associations by consensus.

SRIP3 by MAP2K1 expression — SKCM

Explore this box plot interactively →