MAP2K1

Across TCGA cell cohorts, MAP2K1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,356 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAP2K1-associated GO terms across cancer lineages are Positive regulation of purine nucleotide biosynthetic process, Positive regulation of ATP biosynthetic process, and Positive regulation of nucleotide biosynthetic process. Each is linked with MAP2K1 in more than 14 cancer types. Because this analysis shows association rather than direction, both MAP2K1-to-partner and partner-to-MAP2K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of purine nucleotide biosynthetic process grouped by MAP2K1-low versus MAP2K1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K1→partner) and Y-score (partner→MAP2K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of purine nucleotide biosynthetic process →	+0.203	+1.087	<.001	<.001	3	15
BONE	Positive regulation of ATP biosynthetic process →	+0.185	+1.064	<.001	<.001	3	15
BONE	Positive regulation of nucleotide biosynthetic process →	+0.203	+1.087	<.001	<.001	3	15
STOMACH	Regulation of Golgi inheritance →	+0.156	+0.881	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of purine nucleotide biosynthetic process →	+0.140	+0.897	<.001	<.001	3	12
BONE	Regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.172	+1.052	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,356 associations by consensus.

Positive regulation of purine nucleotide biosynthetic process by MAP2K1 expression — BONE

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