MAP2

Across TCGA patient cohorts, MAP2 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2-associated genes across cancer lineages are ASNS, Rictor_pT1135, and ATM. Each is linked with MAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP2-to-partner and partner-to-MAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MAP2-low versus MAP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2→partner) and Y-score (partner→MAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.395	+2.321	.031	.006	3	4
STAD	Rictor_pT1135 →	-0.106	-1.502	.037	.027	3	4
UCEC	ATM →	-0.310	-1.099	.012	.016	3	4
UCEC	PCNA →	+0.160	+1.716	.006	.003	3	3
UCEC	STAT3_pY705 →	-0.280	-1.099	<.001	.016	3	3
STAD	4E-BP1 →	+0.323	+3.700	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

ASNS by MAP2 expression — LUAD

Explore this box plot interactively →